Cartilage Tissue Engineering Lab

May 16, 2012

Cartilage Tissue Engineering Lab at UCSD

Welcome to the UCSD CTE Lab
For the latest discoveries by the lab, see our publications.
Original Research Chan EF, Harjanto R, Asahara H, Inoue N, Masuda K, Bugbee WD, Firestein GS, Hosalkar HS, Lotz MK, Sah RL: Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am 43:173-85, 2012. PMCID:PMC3321216 [PubMed] Han EH, Ge C, Chen AC, Schumacher BL, Sah RL: Compaction enhances extracellular matrix content and mechanical properties of tissue engineered cartilaginous constructs. Tissue Eng Part A ePub:Apr 2, 2012. [PubMed] Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL: A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med 4:15-37, 2012. [PubMed] more publications Reviews Lotz M, Otsuki S, Grogan SP, Sah RL, Terkeltaub R, DLima DD: Cartilage cell clusters. Arthritis Rheum 62:2206-18, 2010. PMCID:PMC2921934 [PubMed] Williams GM, Chan EF, Temple-Wong MM, Bae WC, Masuda K, Bugbee WD, Sah RL: Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints. J Biomech 43:156-65, 2010. PMCID:PMC2813363 [PubMed] Recent News 5/3/2012 - MicroCT scan of a Sand Dollar Image and video by Esther Cory using Skyscan 1076 4/1/2012 - Fall, BENG 87: Articular Cartilage and Intervertebral Disc: Damage and Degeneration / Translational Profs. Sah and Masuda will offer a freshman seminar this coming Fall, BENG 87: Articular Cartilage and Intervertebral Disc: Damage and Degeneration / ...[more] 6/2/2011 - Barb Schumacher, Kyle Jadin, and Robert Sah cited in Editorial in A&R Mollenhauer JA: Closing ranks: The chondrocytes' move in bad times or biomechanical job sharing? Arthritis Rheum 63:1475-6, 2011. more news
The Cartilage Tissue Engineering Laboratory in the Department of Bioengineering at the University of California, San Diego was formed in July, 1992 by Prof. Robert Sah. Principal Investigators of the CTE Lab are Prof. William Bugbee (Orthopaedic Surgery), Prof. Deborah Watson (Head and Neck Surgery), as well as the director of the lab, Prof. Robert Sah. We are members of the Institute of Engineering in Medicine and also the UCSD Stein Institute for Research on Aging.
In the CTE Lab, we study the *biological processes* of cartilage development & growth aging degeneration repair, regeneration, & replacement by examining the *relationships* between tissue metabolism composition biomechanics structure with the ultimate goal of *improving clinical* treatment diagnosis prevention.
Our studies are currently supported by grants from the following government agencies and foundations, including:
Howard Hughes Medical Institute National Institutes of Health National Science Foundation Veterans Administration Medical Center Veterans Affairs Research & Development
as well as contracts, grants, and gifts from various industries, including:
Arthrex Articular Engineering	BREG Synthasome
We collaborate with several groups at UCSD in the Department of Bioengineering within the Jacobs School of Engineering, as well as the Departments of Orthopaedics, Rheumatology, and Radiology within the School of Medicine. We also enjoy active collaborations with experts outside of UCSD, including Prof. Steve Klisch at California Polytechnic State University-San Luis Obispo. We welcome inquiries from interested individuals. Individuals with interest in doing research in the lab can inquire about research opportunities. PLEASE NOTE! Patients interested in clinical care are encouraged to contact the principal investigators who are practicing physicians. For joint replacement & arthritis surgery or cartilage restoration & transplantation, please contact the clinical office of William Bugbee, MD at Scripps Clinic, or the Department of Orthopaedic Surgery at UCSD. For facial plastic or facial reconstructive surgery, please contact Deborah Watson, MD, Co-director, Facial Plastic and Reconstructive Surgery at the UCSD Medical Center. UCSD Medical Center also offers specialty services in clinical orthopaedics in the areas of sports medicine, rehabilitation medicine and physical therapy.