Cartilage Tissue Engineering Lab at UCSD

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Welcome to the UCSD CTE Lab

For the latest discoveries by the lab, see our publications.

Recent Events

2/21/2008 - Megan Blewis awarded Best Bioengineering Poster More than 240 students presented their research results in the UCSD Jacobs School of Engineering 27th Annual Research Expo. She presented "Interactive cytokine regulation of synoviocyte and PRG4 secretion rates."

2/15/2008 - * NEW * UCSD Bioengineering Research Experiences for Undergraduates (REU) NSF Program Site The UCSD Department of Bioengineering is pleased to announce a National Science Foundation REU program in Regenerative Medicine, Multi-Scale Bioengineering, and Systems Biology. Undergraduates, especially those pursuing undergraduate studies outside of UCSD, are encouraged to apply.

more news

Recent Publications

Kitahara S, Nakagawa K, Sah RL, Wada Y, Ogawa T, Moriya H, Masuda K : In vivo maturation of scaffold-free engineered articular cartilage on hydroxyapatite. Tissue Eng ePub:7.11.08, 2008.
Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D'Lima D, Lotz M: The effect of glycosaminoglycan loss on chrondrocyte viability. Arthritis Rheum 58:1076-85, 2008.
Asanbaeva A, Tam J, Schumacher BL, Klisch SM, Masuda K, Sah RL: Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent. Arch Biochem Biophys 474:175-82, 2008.
Williams GM, Klisch SM, Sah RL: Bioengineering cartilage growth, maturation and form. Pediatr Res 63:527-34, 2008.
Gratz KR, Sah RL: Experimental measurement and quantification of frictional contact between biological surfaces experiencing large deformation and slip. J Biomech 41:1333-40, 2008.
more publications

The Cartilage Tissue Engineering Laboratory in the Department of Bioengineering at the University of California, San Diego was formed in July, 1992 by Prof. Robert Sah. Principal Investigators of the CTE Lab are Prof. William Bugbee (Orthopaedic Surgery), Prof. Deborah Watson (Head and Neck Surgery), as well as the director of the lab, Prof. Robert Sah. We are members of the UCSD Whitaker Institute for Biomedical Engineering and also the UCSD Stein Institute for Research on Aging.

In the CTE Lab, we study the biological processes of cartilage

development & growth
aging
degeneration
repair, regeneration, & replacement

by examining the relationships between tissue

metabolism
composition
biomechanics
structure

with the ultimate goal of improving clinical

treatment
diagnosis
prevention.

Our studies are currently supported by grants from the following government agencies and foundations, including:

as well as contracts, grants, and gifts from various industries, including:

We collaborate with several groups at UCSD in the Department of Bioengineering within the Jacobs School of Engineering, as well as the Departments of Orthopaedics, Rheumatology, and Radiology within the School of Medicine. We also enjoy active collaborations with experts outside of UCSD. We welcome inquiries from interested individuals.

Individuals with interest in doing research in the lab can inquire about research opportunities.

PLEASE NOTE! Patients interested in clinical care are encouraged to contact the principal investigators who are practicing physicians.

For joint replacement & arthritis surgery or cartilage restoration & transplantation, please contact the clinical office of William Bugbee, MD at Scripps Clinic, or the Department of Orthopaedic Surgery at UCSD.

For facial plastic or facial reconstructive surgery, please contact Deborah Watson, MD, Co-director, Facial Plastic and Reconstructive Surgery at the UCSD Medical Center.

UCSD Medical Center also offers specialty services in clinical orthopaedics in the areas of sports medicine, rehabilitation medicine and physical therapy.