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Cartilage Tissue Engineering Lab at UCSD
Lab News

Past Events

11/1/2009 - NYC Marathon for Arthritis Foundation's Let Move Together Team
Jennifer Antonacci, PhD Candidate, will be running the 2009 NYC Marathon on November 1 to raise $2,500 for the Arthritis Foundation's Let's Move Together team(R), a nationwide movement led by the Arthritis Foundation that encourages people to move to prevent or treat arthritis. The charity is a great opportunity for her to contribute back to an organization with similar goals as the CTE Lab. Jennifer Hwang, another PhD candidate will also be running the NYC Marathon.
7/28/2009 - CTE Research Included in SDSC Genomics Workshop
The CTE lab had a unique opportunity to connect with high school teachers from around the country. The teachers came from as far as Wisconsin to a Genomics Workshop hosted by the San Diego Supercomputer Center. The CTE lab invited the 8 teachers to see how genomics is used in the laboratory setting.
7/8/2009 - Press Conference with Lois Capps featuring Prof Steve Klisch
Collaborating Professor Steve Klisch of Cal Poly was recently featured at the press conference of Lois Capps, Congresswoman for Santa Barbara and San Luis Obispo. Professor Klisch appears on the video at ~11min, 30s, describing his use of ARRA funds for undergraduate research. Congratulations to Prof. Klisch!!
5/7/2009 - Jacqueline Greene, UCSD MS-II, awarded Research Training Fellowship for Medical Students from HHMI
Jacqueline Greene, a second year medical student at UCSD, was one of the awardees of a prestigious fellowship from the Howard Hughes Medical Institute. Last summer, in 2008, Jacqueline made outstanding progress in research in the CTE lab. With exciting preliminary results in hand, Jacqueline has planned to spend one year full-time, between her second and third years of medical school, to continue her research. Now, through the HHMI Research Training Fellowships for Medical Students Program, Jacqueline will be fully supported starting in the summer of 2009.
4/4/2009 - CTE Lab Researchers Host Lab Tours during Admit Day
UCSD hosted the annual Admit Day, an event intended to inspire prospective college school students to attend UCSD, introduce them to campus facilities, and provide information for intended degree programs. The CTE lab participated in Admit Day by opening its doors to the prospective students.
2/18/2009 - CTE Lab Undergraduates Host Lab Tours during ENSPIRE
Each year during Engineering Week at UCSD, the Triton Engineering Student Council hosts ENSPIRE, an outreach event with the goal of inspiring middle school students to pursue science and engineering degrees in college.
1/23/2009 - CTE Lab at the First Annual BMES Lab Fair
CTE researchers helped inaugurate the Annual UCSD Biomedical Engineering Society (BMES) Lab Fair. The Lab Fair was initiated by BMES to facilitate communication between freshmen and sophomores in Bioengineering and research labs within the department. Thanks to all those who visited the CTE table!
1/10/2009 - TESC Girls' Day Out at CTE Lab
The CTE lab has participated in another TESC outreach event: Girls Day Out. This new program was organized to encourage girls to pursue science and engineering degrees in college. The Cartilage Tissue Engineering (CTE) lab participated in Girls Day Out activities by giving tours through the lab to roughly 40 students.
12/24/2008 - Attention - Medical Students interested in research with the CTE Lab in Summer 2009
Applications are encouraged from medical students, both at UCSD and elsewhere, to join us for research in the Summer of 2009. Applicants should fill out the form in the "Research Inquiry" section. Applicants from UCSD should also contact the CTE PI with whom they are interested in working, Prof. Sah, Bugbee, or Watson. Applicants from outside of UCSD who are interested in the mechanisms and treatment of osteoarthritis should consider applying to UCSD and the CTE lab via the 2009 Medical Student Training in Aging Research (MSTAR) Program of the The American Federation for Aging Research (AFAR); the deadline for the AFAR application is February 6, 2009, and more information is available at www.afar.org/medstu.html.
12/23/2008 - CTE Contribution to 150th Anniversary Edition of Gray's Anatomy
We are delighted to have contributed to the newest edition of the classic book, Gray's Anatomy. The Anatomical Basis of Clinical Practice. Gray's Anatomy is considered the definitive reference book for courses in human anatomy, and sometimes referred to as "The Doctors' Bible". Google Scholar indicates a large number of citations, 2519 at present, to the 1989 version. The first edition of this extraordinary book was published in 1858, and the 2008 version is the 40th edition, celebrating the 150-year anniversary.
Our contribution was to chapter 5 on "Functional anatomy of the musculoskeletal system" of the the first main section on "Cells, Tissue, and Systems" [1]. The sub-section "Articular hyaline cartilage" starts as follows: "Articular hyaline cartilage covers articular surfaces in synovial joints (Fig. 5.4). ..." (page 83). The referred to Figure 5.4 on page 84 is a DVI image, similar to those appearing in [2-4] and on the CTE homepage. The caption to Figure 5.4 is as follows [2]:
Fig. 5.4 Articular cartilage from the anterior region of the lateral femoral condyle of a young adult human female. Shown are the articular surface (top), articular cartilage and subchondral bone (below). Note the changes in size and spatial distribution of articular chondrocytes through the thickness of the cartilage. 3-D digital volumetric fluorescence imaging of serially sectioned, eosin-Y and acridine orange-stained tissue. (Provided by courtesy of Professor Robert L Sah, Drs Won C Bae, Kyle D Jadin, Benjamin L Wong, Kelvin W. Li and Mrs Barbara L. Schumacher, Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California, San Diego.)
References:
[1] Wigley CB. Chapter 5. Functional anatomy of the musculoskeletal system. Section 1. Cells, Tissues, and Systems. In Gray's Anatomy. The Anatomical Basis of Clinical Practice, 40th edition. 2008. Ed. Susan Standring. Elsevier: London. 1551pp.
[2] Sah RL: The biomechanical faces of articular cartilage. In: The Many Faces of Osteoarthritis, ed by KE Kuettner and VC Hascall, Raven Press, New York, 2002, pp 409-22.
[3] Jadin KD, Bae WC, Schumacher BL, Sah RL: Three-dimensional (3-D) imaging of chondrocytes in articular cartilage: growth-associated changes in cell organization. Biomaterials 28:230-9, 2007. PMID 16999994.
[4] Jadin KD, Wong BL, Bae WC, Li KW, Williamson AK, Schumacher BL, Price JH, Sah RL: Depth-varying density and organization of chondrocytes in immature and mature bovine articular cartilage assessed by 3d imaging and analysis. J Histochem Cytochem 53:1109-19, 2005. PMID 15879579.
4/26/2008 - CTE Promotes Engineering Exploration
Based on the success of ENSPIRE, TESC created Engineering Explorations to give high school students the same encouragement to pursue science and engineering career paths. Researchers in the Cartilage Tissue Engineering (CTE) lab participated the new Engineering Explorations by hosting lab tours.
4/12/2008 - New UCSD Admits Tour CTE Lab
Admit Day is an event aimed at encouraging new admits to attend UCSD by showing them what the campus has to offer. The Cartilage Tissue Engineering (CTE) lab assisted in this effort, showing roughly 60 students and parents a variety of exciting research projects completed by undergraduate students in the lab.
4/5/2008 - Jacobs Scholars Tour the CTE Lab
The Jacobs School of Engineering (JSOE) held a reception for Jacobs Scholars, during which several labs in the JSOE opened their doors to visitors. The CTE lab participated in these tours in order to promote orthopaedic research and tissue engineering.
2/21/2008 - Megan Blewis awarded Best Bioengineering Poster
More than 240 students presented their research results in the UCSD Jacobs School of Engineering 27th Annual Research Expo. She presented "Interactive cytokine regulation of synoviocyte and PRG4 secretion rates."
2/19/2008 - CTE Lab Students Host Lab Tours during ENSPIRE
The Triton Engineering Student Council hosts this event each year during Engineering Week at UCSD. Graduate and undergraduate students in the Cartilage Tissue Engineering (CTE) Lab participated in ENSPIRE this year by hosting lab tours.
2/15/2008 - UCSD Bioengineering Research Experiences for Undergraduates (REU) NSF Program Site
The UCSD Department of Bioengineering is pleased to announce a National Science Foundation REU program in Regenerative Medicine, Multi-Scale Bioengineering, and Systems Biology. Undergraduates, especially those pursuing undergraduate studies outside of UCSD, are encouraged to apply.
1/14/2008 - Lisa Serventi featured in 'Engineering - Go For It!'
The publication is designed to attract high school students and their parents and teachers to the wide world of engineering and technology. It does this by focusing on the things and activities and people that inform teens' lives and value.
1/9/2008 - CTE Lab Researchers Reach Out in Outreach Event at BODIES
Members of the Cartilage Tissue Engineering (CTE) Lab presented information on bioengineering and orthopedic research at outreach events for high school students in January and November. The events were held at the BODIES exhibit in conjunction with UCSD BioBridge to encourage students making the college decision to choose science and engineering majors.
11/7/2007 - Espoir Kyubwa won 1st place in Quantitative Science Oral Presentation at ABRCMS
He presented his research on "In vitro Calcification of Immature Articular Cartilage: Tissue Engineering an Osteochondral Interface" during the Annual Biomedical Research Conference for Minority Students (ABRCMS) in Austin, Texas. Espoir is the President of the NSBE student chapter.
6/8/2007 - Andrea Pallante recognized with TA Excellence Award
for outstanding work in BENG 112B Biomechanics
5/17/2007 - Elaine Chan selected as 2007 AWIS-SD scholarship recipient
The Scholarship Committee selected nine outstanding women applicants at different levels of their academic careers as this year's AWIS scholarships winners. Their academic interests and chosen fields of study cover a number of scientific disciplines, including: Mathematics, Mechanical Engineering, Aerospace Engineering, Human Biology, Ecology/ Behavior/ Evolution, Psychology, Nursing, Cell and Molecular Biology, and Bioengineering.
3/23/2007 - Jessica Lin, Undergraduate Researcher with the CTE Lab, Awarded Goldwater Scholarship
Jessica Lin received one of the highly prestigious Barry Goldwater Scholarships for the 2007-2008 academic year. Jessica is one of two UCSD students who received such a scholarship this year. Jessica is lead organizer of Bioengineering Day 2007 (http://bmes.ucsd.edu/bengday). Congratulations, Jessica!
3/17/2007 - Jen Hwang, graduate student researcher in the CTE Lab recognized at 2007 UCSD BGRS
Graduate student Jen Hwang received another poster prize, this time second-best poster, at the 2007 Bioengineering Graduate Research Symposium. Congratulations, Jen!
3/1/2007 - Feature on Tissue Engineering Laboratory: Cartilage by Nature and by Design
in Tissue Engineering International & Regenerative Medicine Society Fall 2006 Volume 1, Issue 4, p19-26.
2/22/2007 - CTE graduate student researchers recognized at 2007 Research Expo
Jennifer Hwang and Gregory Williams, PhD candidates in the CTE lab, received the top two Bioengineering poster presentation awards at the 2007 Research Expo. Jennifer received the Best Poster award for her study "Changes in hydraulic conductance of human subchondral bone plate with progression of osteoarthritis" by Hwang J, Bae WC, Shieu W, Lewis CW, Bugbee WD, Sah RL which she also recently presented at the Orthopaedic Research Society meeting, last week. Gregory received Honorable Mention for his study "Cartilage reshaping via in vitro mechanical loading" by Williams GM, Lin JW, Sah RL which he also recently presented at the Orthopaedic Research Society meeting, last week.
12/5/2006 - Joint Lubrication and Protection Studied
UCSD scientists say sliding forces applied to cartilage surfaces prompt cells in the tissue to produce molecules that lubricate and protect joints.
12/4/2006 - Joint Cartilage Gets Slippery During Flex Time
Sliding forces applied to cartilage surfaces prompt cells in that tissue to produce molecules that lubricate and protect joints.
5/6/2006 - CTE at 2006 Expanding Your Horizons Conference
The annual UCSD EYH conference seeks to encourage young women and increase their interest in science, mathematics, engineering and technology. Participants included 6th and 10th grade girls, and parents, from over 130 schools.
4/5/2006 - Sah Named Howard Hughes Medical Institute Professor of 2006
Professor Sah was named as a 2006 HHMI Professor. The twenty 2006 Professors join the twenty HHMI Professors selected in 2002. HHMI Professors are based on their commitment and innovative plans for engaging undergraduates in science.
3/15/2006 - Matt Davey Earns NCAA Postgraduate Scholarship
Matt Davey earned another postseason award on Wednesday when he was one of 87 male student-athletes across all three NCAA divisions to be awarded the prestigious NCAA Postgraduate Scholarship.
6/3/2005 - 04-05 UCSD Employee of the Year
Auge Sage and Van Wong from CTE Lab are nominated for the 2004-05 UCSD Employee of the YEar
4/2/2005 - CTE Lab hosts tours for the Expanding Your Horizons Conference
The third annual Expanding Your Horizons(EYH Conference) was held on Saturday, April 2nd, at the University of California, San Diego. Participants included 600 girls and 150 parents from over 150 schools in the San Diego
6/25/2004 - 2004 Gordon Research Conference on Muscoloskeletal Biology & Bioengineering
The Gordon Research Conference on Musculoskeletal Biology and Bioengineering (formerly called, Bioengineering and orthopaedic Sciences) has been the premier forum for more than 20 years
6/4/2004 - 03-04 UCSD Employee of the Year
Barbara Schumacher, Michael Voegtline, and Van Wong were nominated from the CTE Lab for the 2003-04 UCSD Employee of the Year Award.
6/1/2003 - New Cartilage for Damaged Joints
Research Update: A Publication of the Arthritis Foundation
5/29/2003 - Treatment of Articular Cartilage Degeneration and Osteoarhritis with Bioengineered Tissues
SIRA: 2002 Annual Research Review
10/6/2001 - UCSD Bioengineers Fabricate Joint Cartilage
University of California, San Diego (UCSD) bioengineers have fabricated cartilage tissue which for the first time mimics the multi-layered structure and cellular functions of natural articular cartilage.
9/29/1997 - UCSD Bioengineering Research Help Create Mechanical Blueprint for Knee Cartilage
A team of bioengineers at the UC San Diego School of Engineering has described in detail for the first time what happens to each of these regions when cartilage is squeezed and flattened as it absorbs impact.

Press Releases

September 6, 2004: "Biological joint replacement on horizon" by Ike Wilson in The Frederick News-Post p18.

"Biomechanical Blueprint for Knee Cartilage"

Rob Schinagl's work on determining the variation in the compressive modulus of knee cartilage as a function of depth from the articular surface has been cited in the news releases, linked below. For his presentation of this study (Schinagl RM, Ting MK, Price JH, Gough DA, Sah RL: Video microscopy to quantitate the inhomogeneous strain within articular cartilage during confined compression. ASME Advances in Bioengineering BED-26:303-306, 1993) at the 1993 Winter Annual Meeting of the ASME, Rob was a Finalist in the Doctoral Student Competition.

Figure. Composite, epifluorescent micrographs of Hoechst 33258-stained chondrocyte nuclei within full-thickness bovine articular cartilage subjected to graded levels of equilibrium confined compression. Images have been filtered and thresholded, so that chondrocyte nuclei appear as white objects on a black background. Uncompressed tissue sample is shown (top) followed by sample at graded levels of compression below (8, 16, 24, and 32% of uncompressed cartilage thickness). Arrows and circles indicate tracking of nuclei from reference state through each level of compression. Reprinted with permission from Schinagl et al., 1997.