Cartilage Tissue Engineering Lab at UCSD

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Publications
Publication listings with a link are available to individuals or organizations with subscriptions to the journal. Articles are in pdf format and require Acrobat Reader to view them.

List by Year: 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1991 1990 1989 1988
List by Topic: Aging & Osteoarthritis, Biochemistry & Metabolism, Focal Defects, Friction, Wear, Lubrication, Growth & Maturation, Mechanobiology, Osteochondral Allografts, PRG4/SZP/Lubricin, Repair, Review, Septal Cartilage Tissue Engineering, Tissue Engineering, Tissue Mechanics, Tissue Structure,
List by Personnel
Biochemistry & Metabolism
Journal Papers
Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol 7:263-76, 2008. Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. Osteoarthritis Cartilage 16:1-11, 2008. Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJ, Davol A, Sah RL: A cartilage growth mixture model with collagen remodeling: validation protocols. J Biomech Eng 130:031006, 2008. Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D'Lima D, Lotz M: The effect of glycosaminoglycan loss on chrondrocyte viability. Arthritis Rheum 58:1076-85, 2008. Schmidt TA, Gastelum NS, Han EH, Nugent-Derfus GE, Schumacher BL, Sah RL: Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1alpa, IGF-I, and TGF-beta1. Osteoarthritis Cartilage 16:90-7, 2008. Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Mechanisms of cartilage growth: Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum 56:188-98, 2007. Blewis ME, Schumacher BL, Klein TJ, Schmidt TA, Voegtline MS, Sah RL: Microenvironment regulation of PRG4 phenotype of chondrocytes. J Orthop Res 25:685-95, 2007. Hicks DL, Sage AB, Shelton E, Schumacher BL, Sah RL, Watson D: Effect of bone morphogenetic proteins 2 and 7 on septal chondrocytes in alginate. Otolaryngol Head Neck Surg 136:373-9, 2007. Klein TJ, Sah RL: Modulation of depth-dependent properties in tissue-engineered cartilage with a semi-permeable membrane and perfusion: a continuum model of matrix metabolism and transport. Biomech Model Mechanobiol 6:21-32, 2007. Liu Tsang V, Chen AA, Cho LM, Jadin KD, Sah RL, DeLong S, West JL, Bhatia SN: Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J 21:790-801, 2007. Nugent-Derfus GE, Chan AH, Schumacher BL, Sah RL: PRG4 exchange between the articular cartilage surface and synovial fluid. J Orthop Res 25:1269-76, 2007. Temple MM, Bae WC, Chen MQ, Lotz M, Amiel D, Coutts RD, Sah RL: Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 15:1042-52, 2007. Williams GM, Lin JW, Sah RL: Cartilage reshaping via in vitro mechanical loading. Tissue Eng 13:2903-11, 2007. Allen T, Robertson CM, Pennock AT, Bugbee WD, Harwood FL, Wong VW, Chen AC, Sah RL, Amiel D: Analysis of stored osteochondral allografts at the time of surgical implantation. Am J Sports Med 33:1479-84, 2005. Chia SH, Homicz MR, Schumacher BL, Thonar EJ, Masuda K, Sah RL, Watson D: Characterization of human nasal septal chondrocytes cultured in alginate. J Am Coll Surg 200:691-704, 2005. Englert C, McGowan KB, Klein TJ, Giurea A, Schumacher BL, Sah RL: Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum 52:1091-9, 2005. McGowan KB, Sah RL: Treatment of cartilage with beta-aminopropionitrile accelerates subsequent collagen maturation and modulates integrative repair. J Orthop Res 23:594-601, 2005. Miyamoto K, An HS, Sah RL, Akeda K, Okuma M, Otten L, Thonar EJ-MA, Masuda K: Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads. Spine 30:2398-405, 2005. Richmon JD, Sage AB, Shelton E, Schumacher BL, Sah RL, Watson D: Effect of growth factors on cell proliferation, matrix deposition, and morphology of human nasal septal chondrocytes cultured in monolayer. Laryngoscope 115:1553-60, 2005. Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL: Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res 23:562-8, 2005. Williams GM, Klein TJ, Sah RL: Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. Acta Biomater 1:625-33, 2005. Schmidt TA, Schumacher BL, Klein TJ, Voegtline MS, Sah RL: Synthesis of proteoglycan 4 by chondrocyte subpopulations in cartilage explants, monolayer cultures, and resurfaced cartilage cultures. Arthritis Rheum 50:2849-57, 2004. DiMicco MA, Sah RL: Dependence of cartilage matrix composition on biosynthesis, diffusion, and reaction. Transport Porous Media 50:57-73, 2003. Homicz MR, Chia SH, Schumacher BL, Masuda K, Thonar EJ, Sah RL, Watson D: Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture. Laryngoscope 113:25-32, 2003. Homicz MR, McGowan KB, Lottman LM, Beh G, Sah RL, Watson D: A compositional analysis of human nasal septal cartilage. Arch Facial Plast Surg 5:53-8, 2003. Klein TJ, Schumacher BL, Schmidt TA, Li KW, Voegtline MS, Masuda K, Thonar EJ-MA, Sah RL: Tissue engineering of stratified articular cartilage from chondrocyte subpopulations. Osteoarthritis Cartilage 11:595-602, 2003. Kurtis MS, Schmidt TA, Bugbee WD, Loeser RF, Sah RL: Integrin-mediated adhesion of human articular chondrocytes to cartilage. Arthritis Rheum 48:110-8, 2003. Li KW, Wang AS, Sah RL: Microenvironment regulation of extracellular signal--regulated kinase activity in chondrocytes. Arthritis Rheum 48:689-99, 2003. Li KW, Wang AS, Sah RL: Microenvironment regulation of extracellular signal--regulated kinase activity in chondrocytes. Arthritis Rheum 48:689-99, 2003. Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen A, Sah RL, Bugbee WD: Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg 85:2111-20, 2003. Chen AC, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL: Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage. Arthritis Rheum 46:3212-7, 2002. Davisson T, Kunig S, Chen AC, Sah RL, Ratcliffe A: Static and dynamic compressions modulate matrix metabolism in tissue engineered cartilage. J Orthop Res 20:842-8, 2002. Davisson TH, Sah RL, Ratcliffe AR: Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures. Tissue Eng 8:807-16, 2002. DiMicco MA, Waters SN, Akeson WH, Sah RL: Integrative articular cartilage repair: dependence on developmental stage and collagen metabolism. Osteoarthritis Cartilage 10:218-25, 2002. Giurea A, DiMicco MA, Akeson WH, Sah RL: Development-associated differences in integrative cartilage repair: roles of biosynthesis and matrix. J Orthop Res 20:1274-81, 2002. Homicz MR, Schumacher BL, Sah RL, Watson D: Effects of serial expansion of septal chondrocytes on tissue-engineered neocartilage composition. Otolaryngol Head Neck Surg 127:398-408, 2002. Hsieh AH, Sah RL, Sung KLP: Biomechanical regulation of type I collagen gene expression in ACLs in organ culture. J Orthop Res 20:325-31, 2002. McGowan KB, Kurtis MS, Lottman LM, Watson D, Sah RL: Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen and Hoechst 33258. Osteoarthritis Cartilage 10:580-7, 2002. DiMicco MA, Sah RL: Integrative cartilage repair: adhesive strength is correlated with collagen deposition. J Orthop Res 19:1105-12, 2001. Kurtis MS, Tu BP, Gaya OA, Mollenhauer J, Knudson W, Loeser RF, Knudson CB, Sah RL: Mechanisms of chondrocyte adhesion to cartilage: role of beta 1 integrins, CD44, and annexin V. J Orthop Res 19:1122-30, 2001. Lane JG, Tontz WL, Bae WC, Chen AC, Sah RL, Amiel D: A morphological, biochemical, and biomechanical assessment of short term effects of osteochondral autograft plug transfer in an animal model. Arthroscopy 17:856-63, 2001. Riley SL, Dutt S, de la Torre R, Chen AC, Sah RL, Ratcliffe A: Formulation of PEG-based hydrogels affects tissue-engineered cartilage construct characteristics. J Mater Sci Mater Med 12:983-90, 2001. Williamson AK, Chen AC, Sah RL: Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res 19:1113-21, 2001. Jin G, Sah RL, Li Y-S, Lotz M, Shyy JY-J, Chien S: Biomechanical regulation of matrix metalloproteinase-9 in chondrocytes. J Orthop Res 18:899-908, 2000. Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy YJ, Sah RL: Mechnical compression modulates proliferation of transplanted chondrocytes. J Orthop Res 18:374-82, 2000. Ahsan T, Lottman LM, Harwood FL, Amiel D, Sah RL: Integrative cartilage repair by beta-aminoproprionitrile. J Orthop Res 17:850-7, 1999. Chen AC, Sah RL: The effect of static compression on proteoglycan synthesis by chondrocytes transplanted to articular cartilage in vitro. J Orthop Res 16:542-50, 1998. Chen AC, Nagrampa JP, Schinagl RM, Lottman LM, Sah RL: Chondrocyte transplantation to articular cartilage explants in vitro. J Orthop Res 15:791-802, 1997. Chen AC, Nguyen TT, Sah RL: Streaming potentials during the confined compression creep test of normal and proteoglycan-depleted cartilage. Ann Biomed Eng 25:269-77, 1997. Chu CR, Dounchis JS, Yoshioka M, Sah RL, Coutts RD, Amiel D: Osteochondral repair using perichondrial cells: a one year study in rabbits. Clin Orthop Relat Res 340:220-9, 1997. Sah RL, Yang AS, Halili RB, Hant JJ, Chen AC, Yoshioka M, Amiel D, Coutts RD: Compressive and swelling properties of rabbit femoral articular cartilage after ACL transection. J Orthop Res 15:197-203, 1997. Reindel ES, Ayroso AM, Chen AC, Chun DM, Schinagl RM, Sah RL: Integrative repair of articular cartilage in vitro: adhesive strength of the interface region. J Orthop Res 13:751-60, 1995. Kim YJ, Sah RL, Grodzinsky AJ, Plaas AHK, Sandy JD: Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys 311:1-12, 1994. Sah RL, Chen AC, Grodzinsky AJ, Trippel SB: Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys 308:137-47, 1994. Sah RL, Doong JYH, Grodzinsky AJ, Plaas AHK, Sandy JD: Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. Arch Biochem Biophys 286:20-9, 1991. Sah RL, Grodzinsky AJ, Plaas AHK, Sandy JD: Effects of tissue compression on the hyaluronate binding properties of newly synthesized proteoglycans in cartilage explants. Biochem J 267:803-8, 1990. Sah RL, Kim YJ, Doong JH, Grodzinsky AJ, Plaas AHK, Sandy JD: Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res 7:619-36, 1989. Kim YJ, Sah RLY, Doong JYH, Grodzinsky AJ: Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-76, 1988.

Biochemistry & Metabolism