Publications

Chan DD, Guilak F, Sah RL, Calve S: Mechanobiology of hyaluronan: Connecting biomechanics and bioactivity in musculoskeletal tissues. Annu Rev Biomed Eng 26:25-47, 2024. DOI:10.1146/annurev-bioeng-073123-120541

Pal China S, Kalyanaraman H, Zhuang S, Cabriales JA, Sah RL, Pilz RB: Protein kinase G2 activation restores Wnt signaling and bone mass in a mouse model of glucocorticoid-induced osteoporosis. JCI Insight ePub:e175089, 2024. DOI:10.1172/jci.insight.175089

van Rosmalen L, Zhu J, Maier G, Gacasan EG, Lin T, Zhemchuzhnikova E, Rothenberg V, Razu S, Deota S, Ramasamy RK, Sah RL, McCulloch AD, Hut RA, Panda S: Multi-organ transcriptome atlas of a mouse model of relative energy deficiency in sport. Cell Metab 36:2015-37, 2024. DOI:10.1016/j.cmet.2024.08.001

Kalyanaraman H, Pal China S, Cabriales JA, Moininazeri J, Casteel DE, Garcia JJ, Wong VW, Chen A, Sah RL, Boss GR, Pilz RB: Protein kinase G2 is essential for skeletal homeostasis and adaptation to mechanical loading in male but not female mice. J Bone Miner Res 38:171-85, 2023. DOI:10.1002/jbmr.4746

Yang S, Jiang W, Ma X, Wang Z, Sah RL, Wang J, Sun Y: Nanoscale morphologies on the surface of 3D-printed titanium implants for improved osseointegration: A systematic review of the literature. Int J Nanomedicine 18:4171-91, 2023. DOI:10.2147/IJN.S409033

Tabbaa SM, Guilak F, Sah RL, Bugbee WD: Fresh osteochondral and chondral allograft preservation and storage media: A systematic review of the literature. Am J Sports Med 50:1702-16, 2022. DOI:10.1177/03635465211016832

Tandon V, Vala RM, Chen A, Sah RL, Patel HM, Pirrung MC, Banerjee S: Syrbactin-class dual constitutive- and immuno-proteasome inhibitor TIR-199 impedes myeloma-mediated bone degeneration in vivo. Biosci Rep 42:BSR20212721, 2022. DOI:10.1042/BSR20212721

Jerban S, Ma Y, Kasibhatla A, Wu M, Szeverenyi N, Guma M, Covey D, D'lima D, Ward SR, Sah RL, Chang EY, Du J, Chung CB: Ultrashort echo time adiabatic T1-rho (UTE-Adiab-T1-rho) is sensitive to human cadaveric knee joint deformation induced by mechanical loading and unloading. Magn Reson Imaging 80:98-105, 2021. DOI:10.1016/j.mri.2021.04.014

Temple-Wong MM, Raleigh AR, Frisbie DD, Sah RL, McIlwraith CW: Effects of an articular cartilage lubrication with a viscosupplement in vitro and in vivo following osteochondral fractures in horses. Am J Vet Res 82:611-8, 2021. DOI:10.2460/ajvr.82.8.611

De Vivo L, Matsushita AK, Kupor D, Luna J, Tierra BA, Sah RL, Lubarda VA, Meyers MA, McKittrick JM, Krysl P, Kuester F: Cholla cactus frames as lightweight and torsionally tough biological materials. Acta Biomater 112:213-24, 2020. DOI:10.1016/j.actbio.2020.04.054

Fattet L, Jung HY, Matsumoto MW, Aubol BE, Kumar A, Adams JA, Chen AC, Sah RL, Engler AJ, Pasquale EB, Yang J: Matrix rigidity controls epithelial-mesenchymal plasticity and tumor metastasis via a mechanoresponsive EPHA2/LYN complex. Dev Cell 54:302-16, 2020. DOI:10.1016/j.devcel.2020.05.031

Jerban S, Lu X, Dorthe EW, Alenezi S, Ma Y, Kakos L, Jang H, Sah RL, Chang EY, D'Lima D, Du J: Correlations of cortical bone microstructural and mechanical properties with water proton fractions obtained from ultrashort echo time (UTE) MRI tricomponent T2* model. NMR Biomed 33:e4233, 2020. DOI:10.1002/nbm.4233

Jerban S, Ma Y, Wan L, Searleman AC, Jang H, Sah RL, Chang EY, Du J: Collagen proton fraction from ultrashort echo time magnetization transfer (UTE-MT) MRI modelling correlates significantly with cortical bone porosity measured with micro-computed tomography (uCT). NMR Biomed 32:e4045, 2019. DOI:10.1002/nbm.4045

Ledgerwood-Lee M, Zifan A, Kunkel DC, Sah R, Mittal RK: High-frequency ultrasound imaging of the anal sphincter muscles in normal subjects and patients with fecal incontinence. Neurogastroenterol Motil 31:e13537, 2019. DOI:10.1111/nmo.13537

Miyazaki S, Diwan AD, Kato K, Cheng K, Bae WC, Sun Y, Yamada J, Muehleman C, Lenz ME, Inoue N, Sah RL, Kawakami M, Masuda K: Correction to: ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model.. Eur Spine J 28:889, 2019. DOI:10.1007/s00586-019-05878-6

Segaliny AI, Cheng JL, Farhoodi HP, Toledano M, Yu CC, Tierra B, Hildebrand L, Liu L, Liao MJ, Cho J, Liu D, Sun L, Gulsen G, Su MY, Sah RL, Zhao W: Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells. EBioMedicine 45:39-57, 2019. DOI:10.1016/j.ebiom.2019.06.047

Caffrey JP, Alonso E, Masuda K, Hunt JP, Carmody CN, Ganey TM, Sah RL: Strains in trussed spine interbody fusion implants are modulated by load and design. J Mech Behav Biomed Mater 80:203-8, 2018. DOI:10.1016/j.jmbbm.2018.02.004

Chan EF, Farnsworth CL, Klisch SM, Hosalkar HS, Sah RL: 3-dimensional metrics of proximal femoral shape deformities in Legg-Calve-Perthes disease and slipped capital femoral epiphysis. J Orthop Res 36:1526-35, 2018. DOI:10.1002/jor.23791

Jerban S, Ma Y, Nazaran A, Dorthe EW, Cory E, Carl M, D'Lima D, Sah RL, Chang EY, Du J: Detecting stress injury (fatigue fracture) in fibular cortical bone using quantitative ultrashort echo time magnetization transfer (UTE-MT): An ex vivo study. NMR Biomed 31:e3994, 2018. DOI:10.1002/nbm.3994

Kalyanaraman H, Schwaerzer G, Ramdani G, Castillo F, Scott BT, Dillmann W, Sah RL, Casteel DE, Pilz RB: Potein kinase G activation reverses oxidative stress and restores osteoblast function and bone formation in male mice with type 1 diabetes. Diabetes 67:607-23, 2018. DOI:10.2337/db17-0965

Miyazaki S, Diwan AD, Kato K, Cheng K, Bae WC, Sun Y, Yamada J, Muehleman C, Lenz ME, Inoue N, Sah RL, Kawakami M, Masuda K: ISSLS PRIZE IN BASIC SCIENCE 2018: Growth differentiation factor-6 attenuated pro-inflammatory molecular changes in the rabbit anular-puncture model and degenerated disc-induced pain generation in the rat xenograft radiculopathy model. Eur Spine J 27:739-51, 2018. DOI:10.1007/s00586-018-5488-1

Nguyen C, Schlesinger KJ, James TW, James KM, Sah RL, Masuda K, Carlson JM: Novel magnetic resonance technique for characterizing mesoscale structure of trabecular bone. R Soc Open Sci 5:180563, 2018. DOI:10.1098/rsos.180563

Ramdani G, Schall N, Kalyanaraman H, Wahwah N, Moheize S, Lee JJ, Sah RL, Pfeifer A, Casteel DE, Pilz RB: cGMP-dependent protein kinase-2 regulates bone mass and prevents diabetic bone loss. J Endocrinol 238:203-19, 2018. DOI:10.1530/JOE-18-0286

Sheng W, Seare WJ, DiBernardo B, Alhasan AH, Cory E, Chasan P, Sah RL, Almutairi KM, Almutairi A: A single-blind study evaluating the efficacy of gold nanoparticle photothermal-assisted liposuction in an ex vivo human tissue model. Aesthet Surg J 38:1213-24, 2018. DOI:10.1093/asj/sjy027

Su AW, Chen Y, Dong Y, Wailes DH, Wong VW, Chen AC, Cai S, Bugbee WD, Sah RL: Biomechanics of osteochondral impact with cushioning and graft Insertion: Cartilage damage is correlated with delivered energy. J Biomech 17:127-36, 2018. DOI:10.1016/j.jbiomech.2018.03.037

Zifan A, Reisert M, Sinha S, Ledgerwood-Lee M, Cory E, Sah R, Mittal RK: Connectivity of the superficial muscles of the human perineum: A diffusion tensor imaging-based global tractography study. Sci Rep 8:17867, 2018. DOI:10.1038/s41598-018-36099-4

Cherkasskiy L, Caffrey JP, Szewczyk AF, Cory E, Bomar JD, Farnsworth CL, Jeffords M, Wenger DR, Sah RL, Upasani VV: Patient-specific 3D models aid planning for triplane proximal femoral osteotomy in slipped capital femoral epiphysis. J Child Orthop 11:147-53, 2017. DOI:10.1302/1863-2548-11-170277

Foster BL, Kuss P, Yadav MC, Kolli TN, Narisawa S, Lukashova L, Cory E, Sah RL, Somerman MJ, Millan JL: Conditional Alpl ablation phenocopies dental defects of hypophosphatasia. J Dent Res 96:81-91, 2017. DOI:10.1177/0022034516663633

He S, Johnson NJJ, Nguyen Huu VA, Cory E, Huang Y, Sah RL, Jokerst JV, Almutairi A : Simultaneous enhancement of photoluminescence, MRI relaxivity, and CT contrast by tuning the interfacial layer of lanthanide heteroepitaxial nanoparticles. Nano Lett 17:4873-80, 2017. DOI:10.1021/acs.nanolett.7b01753

Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB: A novel, direct NO donor regulates osteoblast and osteoclast functions and increases bone mass in ovariectomized mice. J Bone Miner Res 32:46-59, 2017. DOI:10.1002/jbmr.2909

Meinert C, Schrobback K, Levett PA, Lutton C, Sah RL, Klein TJ: Tailoring hydrogel surface properties to modulate cellular response to shear loading. Acta Biomater 52:105-17, 2017. DOI:10.1016/j.actbio.2016.10.011

Su AW, Chen Y, Wailes DH, Wong VW, Cai S, Chen AC, Bugbee WD, Sah RL: Impact insertion of osteochondral grafts: Interference fit and central graft reduction affect biomechanics and cartilage damage. J Orthop Res 36:377-86, 2017. DOI:10.1002/jor.23645

Sun Y, Jiang W, Cory E, Caffrey JP, Hsu FH, Chen AC, Wang J, Sah RL, Bugbee WD: Pulsed lavage cleaning of osteochondral grafts depends on lavage duration, flow intensity, and graft storage condition. PLoS One 12:e0176934, 2017. DOI:10.1371/journal.pone.0176934

Tabbaa SM, Wong VW, Silberman G, McIlwraith CW, Wimmer MA, Sah RL, Frisbie DD: Early alterations in articular cartilage surface topography in post-traumatic equine model of osteoarthritis. Osteoarthritis Cartilage 25:S331, 2017. DOI:10.1016/j.joca.2017.02.555

Bugbee WD, Pallante-Kichura AL, Görtz S, Amiel D, Sah R: Osteochondral allograft transplantation in cartilage repair: Graft storage paradigm, translational models, and clinical applications. J Orthop Res 34:31-8, 2016. DOI:10.1002/jor.22998

Caffrey JP, Cory E, Wong VW, Masuda K, Chen AC, Hunt JP, Ganey TM, Sah RL: Ex vivo loading of trussed implants for spine fusion induces heterogeneous strains consistent with homeostatic bone mechanobiology. J Biomech 49:4090-7, 2016. DOI:10.1016/j.jbiomech.2016.10.051

Cory E, Sah RL, Ledgerwood MM, Mittal RK: Tu1787 Crossing of muscle fibers at the ventral (12 o'clock) and dorsal (6 o'clock) regions of external anal sphincter: A case of double “purse string” morphology. Gastroenterology 150:S946, 2016. DOI:10.1016/S0016-5085(16)33198-5

deVries MS, Webb SJ, Tu J, Cory E, Morgan V, Sah RL, Deheyn DD, Taylor JRA: Stress physiology and weapon integrity of intertidal mantis shrimp under future ocean conditions. Sci Rep 6:38637, 2016. DOI:10.1038/srep38637

Garfin SR, Sah RL: In memoriam: Wayne Akeson, MD (1928-2016). J Orthop Res 34:2046-7, 2016. DOI:10.1002/jor.23493

Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR: Addition of mesenchymal stem cells to autologous platelet-enhanced fibrin scaffolds in chondral defects: Does it enhance repair?. J Bone Joint Surg 98:23-34, 2016. DOI:10.2106/JBJS.O.00407

Temple-Wong MM, Ren S, Quach P, Hansen BC, Chen AC, Hasegawa A, D'Lima DD, Koziol J, Masuda K, Lotz MK, Sah RL: Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration. Arthritis Res Ther 18:18, 2016. DOI:10.1186/s13075-016-0922-4

Watson D, Reuther MS, Wong VW, Sah RL, Masuda K, Briggs KK: Effect of hyaluronidase on tissue-engineered human septal cartilage. Laryngoscope 126:1984-9, 2016. DOI:10.1002/lary.25720

Yadav MC, Bottini M, Cory E, Bhattacharya K, Kuss P, Narisawa S, Sah RL, Beck L, Fadeel B, Farquharson C, Millán JL: Skeletal mineralization deficits and impaired biogenesis and function of chondrocyte-derived matrix vesicles in Phospho1-/- and Phospho1/Pit1 double knockout mice. J Bone Miner Res 31:1275-86, 2016. DOI:10.1002/jbmr.2790

Chung AM, Bird EM, Maheshwari AJ, Samy KE, Makhijani PN, Dinescu AT, Hansen BC, Chen AC, Cory E, Wong VW, Bugbee WD, Sah RL: Targeting biomimetic 3D soft-hard tissue interfaces: Formation of a calcified spherical shell with a double diffusion bioreactor. Tissue Eng Part A 21:S-352, 2015. DOI:10.1089/ten.tea.2015.5000.abstracts

Doody KM, Stanford SM, Sacchetti C, D Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N: Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy. Sci Transl Med 7:288ra76, 2015. DOI:10.1126/scitranslmed.aaa4616

Foster BL, Sheen CR, Hatch NE, Liu J, Cory E, Narisawa S, Kiffer-Moreira T, Sah RL, Whyte MP, Somerman MJ, Millán JL: Periodontal defects in the A116T knock-in mouse model of odontohypophosphatasia. J Dent Res 94:706-14, 2015. DOI:10.1177/0022034515573273

Hollenstein J, Terrier A, Cory E, Chen AC, Sah RL, Pioletti DP: Mechanical evaluation of a tissue-engineered zone of calcification in a bone-hydrogel osteochondral construct. Comput Methods Biomech Biomed Engin 18:332-7, 2015. DOI:10.1080/10255842.2013.794898

Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J: Matrix stiffness drives epithelial-mesenchymal transition and tumor metastasis via a TWIST1-G3BP2 mechanotransduction pathway. Nat Cell Biol 17:678-88, 2015. DOI:10.1038/ncb3157

Bae WC, Biswas R, Statum S, Sah RL, Chung CB: Sensitivity of quantitative UTE MRI to the biomechanical property of the temporomandibular joint disc. Skeletal Radiol 43:1217-23, 2014. DOI:10.1007/s00256-014-1901-y

Gregory DE, Bae WC, Sah RL, Masuda K: Disc degeneration reduces the delamination strength of the anulus fibrosis in the rabbit anular disc puncture model. Spine J 14:1265-71, 2014. DOI:10.1016/j.spinee.2013.07.489

Grissom MJ, Temple-Wong MM, Adams MS, Tom M, Schumacher BL, McIlwraith CW, Goodrich LR, Chu CR, Sah RL: Synovial fluid lubricant properties are transiently deficient after arthroscopic articular cartilage defect repair with platelet-enriched fibrin alone and with mesenchymal stem cells. Orthop J Sports Med 2:, 2014. DOI:10.1177/2325967114542580

Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB: Soluble guanylate cyclase as a novel treatment target for osteoporosis. Endocrinology 155:4720-30, 2014. DOI:10.1210/en.2014-1343

Kushnaryov A, Yamaguchi T, Briggs KK, Wong VW, Reuther M, Neuman M, Lin V, Sah RL, Masuda K, Watson D: Evaluation of autogenous engineered septal cartilage grafts in rabbits - a minimally invasive preclinical model. Adv Otolaryngol 2014:415821, 2014. DOI:10.1155/2014/415821

Mologne TS, Cory E, Hansen BC, Naso AN, Chang N, Murphy MM, Provencher MT, Bugbee WD, Sah RL: Osteochondral allograft transplant to the medial femoral condyle using a medial or lateral femoral condyle allograft: Is there a difference in graft sources?. Am J Sports Med 42:2205-13, 2014. DOI:10.1177/0363546514540446

Novitskaya E, Zin C, Chang N, Cory E, Chen PC, D'Lima DD, Sah RL, McKittrick J: Creep of trabecular bone from the human proximal tibia. Mater Sci Eng C Mater Biol Appl 40:219-27, 2014. DOI:10.1016/j.msec.2014.03.057

Twu CW, Reuther MS, Briggs KK, Sah RL, Masuda K, Watson D: Effect of oxygen tension on tissue engineered human nasal septal chondrocytes. Allergy Rhinol (Providence) 5:125-31, 2014. DOI:10.2500/ar.2014.5.0097

Yamaguchi T, Inoue N, Sah RL, Lee YP, Taborek AP, Williams GM, Moseley TA, Bae WC, Masuda K: Micro-computed tomography-based three-dimensional kinematic analysis during lateral bending for spinal fusion assessment in a rat posterolateral lumbar fusion model. Tissue Eng Part C Methods 20:578-87, 2014. DOI:10.1089/ten.TEC.2013.0439

Caffrey JP, Kushnaryov AM, Reuther MS, Wong VW, Briggs KK, Masuda K, Sah RL, Watson D : Flexural properties of native and tissue engineered human septal cartilage. Otolaryngol Head Neck Surg 148:576-81, 2013. DOI:10.1177/0194599812474228

Chan EF, Farnsworth CL, Koziol JA, Hosalkar HS, Sah RL: Statistical shape modeling of proximal femoral shape deformities in Legg-Calve-Perthes disease and slipped capital femoral epiphysis. Osteoarthritis Cartilage 21:443-9, 2013. DOI:10.1016/j.joca.2012.12.007

Neuman MK, Briggs KK, Masuda K, Sah RL, Watson D: A compositional analysis of cadaveric human nasal septal cartilage. Laryngoscope 123:2120-4, 2013. DOI:10.1002/lary.23727

Pallante-Kichura AL, Chen AC, Temple-Wong MM, Bugbee WD, Sah RL: In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretion. J Orthop Res 31:880-6, 2013. DOI:10.1002/jor.22319

Pallante-Kichura AL, Cory E, Bugbee WD, Sah RL: Bone cysts after osteochondral allograft repair of cartilage defects in goats suggest abnormal interaction between subchondral bone and overlying synovial joint tissues. Bone 57:259-68, 2013. DOI:10.1016/j.bone.2013.08.011

Raub CB, Hsu SC, Chan EF, Shirazi R, Chen AC, Chnari E, Semler EJ, Sah RL: Microstructural remodeling of articular cartilage following defect repair by osteochondral autograft transfer. Osteoarthritis Cartilage 21:860-8, 2013. DOI:10.1016/j.joca.2013.03.014

Reuther MS, Briggs KK, Neuman MK, Masuda K, Sah RL, Watson D: Shape fidelity of native and engineered human nasal septal cartilage. Otolaryngol Head Neck Surg 148:753-7, 2013. DOI:10.1177/0194599813478921

Stender ME, Raub CB, Yamauchi KA, Shirazi R, Vena P, Sah RL, Hazelwood SJ, Klisch SM: Integrating qPLM and biomechanical test data with anisotropic fiber distribution model and predictions of TGF-beta1 adn IGF-1 regulation of articular cartilage fiber modulus. Biomech Model Mechanobiol 12:1073-88, 2013. DOI:10.1007/s10237-012-0463-y

Zhang B, Cory E, Bhattacharya R, Sah RL, Hargens AR: Fifteen days of microgravity causes growth in calvaria of mice. Bone 56:290-5, 2013. DOI:10.1016/j.bone.2013.06.009

Antonacci JM, Schmidt TA, Serventi LA, Cai MZ, Shu YL, Schumacher BL, McIIwraith CW, Sah RL: Effects of equine joint injury on boundary lubrication of articular cartilage by synovial fluid: role of hyaluronan. Arthritis Rheum 64:2917-26, 2012. DOI:10.1002/art.34520

Balcom NT*, Berg-Johansen B*, Dills KJ, Van Donk JR, Williams GM, Chen AC, Hazelwood SJ, Sah RL, Klisch SM: In vitro articular cartilage growth with sequential application of IGF-1 and TGF-beta1 enhances volumetric growth and maintains compressive properties. J Biomech Eng 134:031001, 2012. DOI:10.1115/1.4005851

Ballard BL*, Antonacci JM*, Temple-Wong MM, Hui AY, Schumacher BL, Bugbee WD, Schwartz AK, Girard PJ, Sah RL: Effect of tibial plateau fracture on lubrication function and composition of synovial fluid. J Bone Joint Surg 94:e641-9, 2012. DOI:10.2106/JBJS.K.00046

Chan EF, Harjanto R, Asahara H, Inoue N, Masuda K, Bugbee WD, Firestein GS, Hosalkar HS, Lotz MK, Sah RL: Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am 43:173-85, 2012. DOI:10.1016/j.ocl.2012.01.005

Chan EF, Liu E, Semler E, Aberman H, Simon T, Truncale K, Chen AC, Sah RL: Association of 3-dimensional cartilage and bone structure with articular cartilage properties in and adjacent to autologous osteochondral grafts after 6 and 12 months in a goat model. Cartilage 3:255-66, 2012. DOI:10.1177/1947603511435272

Chang AA, Reuther MS, Briggs KK, Schumacher BL, Williams GM, Corr M, Sah RL, Watson D: In vivo implantation of tissue-engineered human nasal septal neocartilage constructs: a pilot study. Otolaryngol Head Neck Surg 146:46-52, 2012. DOI:10.1177/0194599811425141

Gokhin DS, Nowak RB, Kim NE, Arnett EE, Chen AC, Sah RL, Clark JI, Fowler VM: Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens. PLoS One 7:e48734, 2012. DOI:10.1371/journal.pone.0048734

Gregory DE, Bae WC, Sah RL, Masuda K: Anular delamination strength of human lumbar intervertebral disc. Eur Spine J 21:1716-23, 2012. DOI:10.1007/s00586-012-2308-x

Hammaker D, Topolewski K, Edgar M, Yoshizawa T, Fukushima A, Boyle DL, Cory Burak E, Sah RL, Firestein GS: Decreased collagen-induced arthritis severity and adaptive immunity in MKK-6-deficient mice. Arthritis Rheum 64:678-87, 2012. DOI:10.1002/art.33359

Han EH, Ge C, Chen AC, Schumacher BL, Sah RL: Compaction enhances extracellular matrix content and mechanical properties of tissue engineered cartilaginous constructs. Tissue Eng Part A 18:1151-60, 2012. DOI:10.1089/ten.TEA.2011.0300

Hui AY, McCarty WJ, Masuda K, Firestein GS, Sah RL: A systems biology approach to synovial joint lubrication in health, injury, and disease. Wiley Interdiscip Rev Syst Biol Med 4:15-37, 2012. DOI:10.1002/wsbm.157

Kushnaryov A, Wong V, Reuther MS, Briggs K, Sah RL, Masuda K, Watson D: Flexural modulus in tissue-engineered human septal cartilage. Otolaryngol Head Neck Surg 147:P111, 2012. DOI:10.1177/0194599812451438a237

McCarty WJ, Cheng JC, Hansen BC, Yamaguchi T, Firestein GS, Masuda K, Sah RL: The biophysical mechanisms of altered hyaluronan concentration in synovial fluid after anterior cruciate ligament transection. Arthritis Rheum 64:3993-4003, 2012. DOI:10.1002/art.37682

Nguyen QT, Hwang YS, Chen AC, Varghese S, Sah RL: Cartilage-like mechanical properties of poly (ethylene glycol)-diacrylate hydrogels. Biomaterials 33:6682-90, 2012. DOI:10.1016/j.biomaterials.2012.06.005

Pallante AL, Chen AC, Ball ST, Amiel D, Masuda K, Sah RL, Bugbee WD: The in vivo performance of osteochondral allografts in the goat is diminished with extended storage and decreased cartilage cellularity. Am J Sports Med 40:1814-23, 2012. DOI:10.1177/0363546512449321

Pallante AL, Gortz S, Chen AC, Healey RM, Chase DC, Ball ST, Amiel D, Sah RL, Bugbee WD: Treatment of articular cartilage defects in the goat with frozen versus fresh osteochondral allografts: effects on cartilage stiffness, zonal composition, and structure at six months. J Bone Joint Surg 94:1984-95, 2012. DOI:10.2106/JBJS.K.00439

Reuther MS, Wong VW, Briggs KK, Chang AA, Nguyen QT, Schumacher BL, Masuda K, Sah RL, Watson D: Culture of human septal chondrocytes in a rotary bioreactor. Arch Otolaryngol Head Neck Surg 147:661-7, 2012. DOI:10.1177/0194599812448049

Yadav MC, de Oliveira RC, Foster BL, Fong H, Cory E, Narisawa S, Sah RL, Somerman M, Whyte MP, Millan JL: Enzyme replacement prevents enamel defects in hypophosphatasia mice. J Bone Miner Res 27:1722-34, 2012. DOI:10.1002/jbmr.1619

Anderson WA, Amasino RM, Ares M Jr, Banerjee U, Bartel B, Corces VG, Drennan CL, Elgin SC, Epstein IR, Fanning E, Guillette LJ Jr, Handelsman J, Hatfull GF, Hoy RR, Kelley D, Leinwand LA, Losick R, Lu Y, Lynn DG, Neuhauser C, O'Dowd DK, Olivera T, Pevzner P, Richards-Kortum RR, Rine J, Sah RL, Strobel SA, Walker GC, Walt DR, Warner IM, Wessler S, Willard HF, Zare RN: Competencies: a cure for pre-med curriculum. Science 334:760-1, 2011. DOI:10.1126/science.334.6057.760-b

Bhardwaj N*, Nguyen QT*, Chen AC, Kaplan DL, Sah RL, Kundu SC: Potential of 3-D tissue constructs engineered from bovine chondrocytes / silk fibroin-chitosan for in vitro cartilage tissue engineering. Biomaterials 32:5773-81, 2011. DOI:doi:10.1016/j.biomaterials.2011.04.061

Han E, Chen SS, Klisch SM, Sah RL: Contribution of proteoglycan osmotic swelling pressure to the compressive properties of articular cartilage. Biophys J 101:916-24, 2011. DOI:10.1016/j.bpj.2011.07.006

Hurtig M, Buschmann MD, Fortier L, Hoemann CD, Hunziker EB, Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL, Whiteside RA: Preclinical studies for cartilage repair: recommendations from the International Cartilage Repair Society. Cartilage 2:137-52, 2011. DOI:10.1177/1947603511401905

Li L, Patil S, Steklov N, Bae W, Temple-Wong M, D'Lima DD, Sah RL, Fregly BJ: Computational wear simulation of patellofemoral articular cartilage during in vitro testing. J Biomech 44:1507-13, 2011. DOI:10.1016/j.jbiomech.2011.03.012

McCarty WJ, Luan A, Siddiqui M, Hansen BC, Masuda K, Sah RL: Biomechanical properties of mixtures of blood and synovial fluid. J Orthop Res 29:240-6, 2011. DOI:10.1002/jor.21209

McCarty WJ, Luan A, Sundaramurthy P, Urbanczyk C, Patel A, Hahr J, Sotoudeh M, Ratcliffe A, Sah RL: An arthroscopic device to assess articular cartilage defects and treatment with a hydrogel. Ann Biomed Eng 39:1306-12, 2011. DOI:10.1007/s10439-010-0209-x

McCarty WJ, Masuda K, Sah RL: Fluid movement and joint capsule strains due to flexion in rabbit knees. J Biomech 44:2761-7, 2011. DOI:10.1016/j.jbiomech.2011.09.005

Sanal HT, Bae WC, Pauli C, Du J, Statum S, Znamirowski R, Sah RL, Chung CB: Magnetic resonance imaging of the temporomandibular joint disc: feasibility of novel quantitative magnetic resonance evaluation using histologic and biomechanical reference standards. J Orofac Pain 25:345-53, 2011. 

Shirazi R, Vena P, Sah RL, Klisch SM: Modeling the collagen fibril network of biological tissues as a nonlinearly elastic material using a continuous volume fraction distribution function. Math Mech Solids 16:706-15, 2011. DOI:10.1177/1081286510387866

Talukdar S*, Nguyen QT*, Chen AC, Sah RL, Kundu SC: Effect of initial cell seeding density on 3D-engineered silk fibroin scaffolds for articular cartilage tissue engineering. Biomaterials 32:8927-37, 2011. DOI:10.1016/j.biomaterials.2011.08.027

Upasani VV, Farnsworth CL, Chambers RC, Bastrom TP, Williams GM, Sah RL, Masuda K, Newton PO: Intervertebral disc health preservation after six months of spinal growth modulation. J Bone Joint Surg 93:1408-16, 2011. DOI:10.2106/JBJS.J.00247

Williams GM, Sah RL: In vitro modulation of cartilage shape plasticity by biochemical regulation of matrix remodeling. Tissue Eng Part A 17:17-23, 2011. DOI:10.1089/ten.TEA.2010.0177

Yadav MC, Lemire I, Leonard P, Boileau G, Blond L, Beliveau M, Cory E, Sah RL, Whyte MP, Crine P, Millan JL: Dose response of bone-targeted enzyme replacement for murine hypophosphatasia. Bone 49:250-6, 2011. DOI:10.1016/j.bone.2011.03.770

Alexander TH, Sage AB, Chen AC, Schumacher BL, Shelton E, Masuda K, Sah RL, Watson D: Insulin-like growth factor-I and growth differentiation factor-5 promote the formation of tissue-engineered human nasal septal cartilage. Tissue Eng Part C Methods 16:1213-21, 2010. DOI:10.1089/ten.TEC.2009.0396

Bae WC, Dwek JR, Znamirowski R, Statum S, Hermida JC, D'Lima DD, Sah RL, Du J, Chung CB: Ultrashort echo time MR imaging of the osteochondral junction of the knee at 3 T: Identification of anatomic structures contributing to signal intensity. Radiology 254:837-45, 2010. DOI:10.1148/radiol.09081743

Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, Lotz MK, Coutts RD, Bugbee WD, Sah RL: Topographic patterns of cartilage lesions in knee osteoarthritis. Cartilage 1:10-9, 2010. DOI:10.1177/1947603509354991

Blewis ME, Lao BJ, Jadin KD, McCarty WJ, Bugbee WD, Firestein GS, Sah RL: Semi-permeable membrane retention of synovial fluid lubricants hyaluronan and proteoglycan 4 for a biomimetic bioreactor. Biotechnol Bioeng 106:149-60, 2010. DOI:10.1002/bit.22645

Blewis ME, Lao BJ, Schumacher BL, Bugbee WD, Sah RL, Firestein GS: Interactive cytokine regulation of synoviocyte lubricant secretion. Tissue Eng Part A 16:1329-37, 2010. DOI:10.1089/ten.TEA.2009.0210

Chawla K, Masuda K, Sah RL: Tracking chondrocytes and assessing their proliferation with carboxyfluorescein diacetate succinimidyl ester: effects on cell functions. Tissue Eng Part C Methods 16:301-10, 2010. DOI:10.1089/ten.tec.2008.0609

Han EH, Wilensky LM, Schumacher BL, Chen AC, Masuda K, Sah RL: Tissue engineering by molecular disassembly and reassembly: biomimetic retention of mechanically functional aggrecan in hydrogel. Tissue Eng Part C Methods 16:1471-9, 2010. DOI:10.1089/ten.TEC.2009.0800

Hwang J, Kyubwa EM, Bae WC, Bugbee WD, Masuda K, Sah RL: In vitro calcification of immature bovine articular cartilage: formation of a functional zone of calcified cartilage. Cartilage 1:287-97, 2010. DOI:10.1177/1947603510369552

Lane JG, Healey RM, Chen AC, Sah RL, Amiel D: Can osteochondral grafting be augmented with microfracture in an extended-size lesion of articular cartilage?. Am J Sports Med 38:1316-23, 2010. DOI:10.1177/0363546510363433

Lotz M, Otsuki S, Grogan SP, Sah RL, Terkeltaub R, DLima DD: Cartilage cell clusters. Arthritis Rheum 62:2206-18, 2010. DOI:10.1002/art.27528

McCarty WJ, Pallante AL, Rone RJ, Bugbee WD, Sah RL: The proteoglycan metabolism of articular cartilage in joint-scale culture. Tissue Eng Part A 16:1717-27, 2010. DOI:10.1089/ten.TEA.2009.0663

Nguyen QT, Wong BL, Chun J, Yoon YC, Talke FE, Sah RL: Macroscopic assessment of cartilage shear: effects of counter-surface roughness, synovial fluid lubricant, and compression offset. J Biomech 43:1787-93, 2010. DOI:10.1016/j.jbiomech.2010.02.014

Sah RL, Ratcliffe A: Translational models for musculoskeletal tissue engineering and regenerative medicine. Tissue Eng Part B Rev 16:1-3, 2010. DOI:10.1089/ten.TEB.2009.0726

Watson D, Sage A, Chang AA, Schumacher BL, Sah RL: Growth of human septal chondrocytes in fibrin scaffolds. Am J Rhinol Allergy 24:e19-22, 2010. DOI:10.2500/ajra.2010.24.3433

Williams GM*, Chan EF*, Temple-Wong MM, Bae WC, Masuda K, Bugbee WD, Sah RL: Shape, loading, and motion in the bioengineering design, fabrication, and testing of personalized synovial joints. J Biomech 43:156-65, 2010. DOI:10.1016/j.jbiomech.2009.09.021

Williams GM, Dills KJ, Flores CR, Stender ME, Stewart KM, Nelson LM, Chen AC, Masuda K, Hazelwood SJ, Klisch SM, Sah RL: Differential regulation of immature articular cartilage compressive moduli and Poisson's ratios by in vitro stimulation with IGF-1 and TGF-beta1. J Biomech 43:2501-7, 2010. DOI:10.1016/j.jbiomech.2010.05.022

Wong BL, Kim SHC, Antonacci JM, McIlwraith CW, Sah RL: Cartilage shear dynamics during tibio-femoral articulation: effect of acute joint injury and tribosupplementation on synovial fluid lubrication. Osteoarthritis Cartilage 18:464-71, 2010. DOI:10.1016/j.joca.2009.11.008

Wong BL, Sah RL: Mechanical asymmetry during articulation of tibial and femoral cartilage: local and overall compressive and shear deformation and properties. J Biomech 43:1689-95, 2010. DOI:10.1016/j.jbiomech.2010.02.035

Wong BL, Sah RL: Effect of a focal articular defect on cartilage deformation during patello-femoral articulation. J Orthop Res 28:1554-61, 2010. DOI:10.1002/jor.21187

Butler DL, Goldstein SA, Guldberg RE, Guo XE, Kamm R, Laurencin CT, McIntire LV, Mow VC, Nerem R, Sah RL, Soslowsky L, Spilker RL, Tranquillo RT: The impact of biomechanics in tissue engineering and regenerative medicine. Tissue Eng Part B Rev 15:477-84, 2009. DOI:10.1089/ten.teb.2009.0340

Gratz KR, Wong BL, Bae WC, Sah RL: The effects of focal articular defects on cartilage contact mechanics. J Orthop Res 27:584-92, 2009. DOI:10.1002/jor.20762

Hsieh-Bonassera ND, Wu I, Lin JK, Schumacher BL, Chen AC, Masuda K, Bugbee WD, Sah RL: Expansion and redifferentiation of chondrocytes from osteoarthritic cartilage: cells for human cartilage tissue engineering. Tissue Eng Part A 15:3513-23, 2009. DOI:10.1089/ten.tea.2008.0628

Klein TJ, Malda J, Sah RL, Hutmacher DW: Tissue engineering of articular cartilage with biomimetic zones. Tissue Eng Part B Rev 15:143-57, 2009. DOI:10.1089/ten.TEB.2008.0563

Muehleman C, Li J, Abe Y, Pfister B, Sah RL, Phipps R, Masuda K: Effect of risedronate in a minipig cartilage defect model with allograft. J Orthop Res 27:360-5, 2009. DOI:10.1002/jor.20775

Pallante AL, Bae WC, Chen AC, Gortz S, Bugbee WD, Sah RL: Chondrocyte viability is higher after prolonged storage at 37{degrees}C than at 4{degrees}C for osteochondral grafts. Am J Sports Med 37:24S-32S, 2009. DOI:10.1177/0363546509351496

Sage A, Chang AA, Schumacher BL, Sah RL, Watson D: Cartilage outgrowth in fibrin scaffolds. Am J Rhinol Allergy 23:486-91, 2009. DOI:10.2500/ajra.2009.23.3347

Temple-Wong MM, Bae WC, Chen MQ, Bugbee WD, Amiel D, Coutts RD, Lotz M, Sah RL: Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 17:1469-76, 2009. DOI:10.1016/j.joca.2009.04.017

Thomas GC, Asanbaeva A, Vena P, Sah RL, Klisch SM: A nonlinear constituent based viscoelastic model for articular cartilage and analysis of tissue remodeling due to altered glycosaminoglycan-collagen interactions. J Biomech Eng 131:101002, 2009. DOI:10.1115/1.3192139

Williams GM, Gratz KR, Sah RL: Asymmetrical strain distributions and neutral axis location of cartilage in flexure. J Biomech 42:325-30, 2009. DOI:10.1016/j.jbiomech.2008.11.009

Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol 7:263-76, 2008. DOI:10.1007/s10237-007-0096-8

Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Cartilage growth and remodeling: modulation of balance between proteoglycan and collagen network in vitro with beta-aminopropionitrile. Osteoarthritis Cartilage 16:1-11, 2008. DOI:10.1016/j.joca.2007.05.019

Asanbaeva A, Tam J, Schumacher BL, Klisch SM, Masuda K, Sah RL: Articular cartilage tensile integrity: modulation by matrix depletion is maturation-dependent. Arch Biochem Biophys 474:175-82, 2008. DOI:10.1016/j.abb.2008.03.012

Bae WC, Wong VW, Hwang J, Antonacci JM, Nugent-Derfus GE, Blewis ME, Temple-Wong MM, Sah RL: Wear-lines and split-lines of human patellar cartilage: relation to tensile biomechanical properties. Osteoarthritis Cartilage 16:841-5, 2008. DOI:10.1016/j.joca.2007.11.015

Davol A, Bingham MS, Sah RL, Klisch SM: A nonlinear finite element model of cartilage growth. Biomech Model Mechanobiol 7:295-307, 2008.DOI:10.1007/s10237-007-0098-6

Gratz KR, Sah RL: Experimental measurement and quantification of frictional contact between biological surfaces experiencing large deformation and slip. J Biomech 41:1333-40, 2008. DOI:10.1016/j.jbiomech.2008.01.006

Gratz KR, Wong BL, Bae WC, Sah RL: The effects of focal articular defects on intra-tissue strain in the surrounding and opposing cartilage. Biorheology 45:193-207, 2008. DOI:10.3233/BIR-2008-0475

Han EH, Bae WC, Hsieh-Bonassera ND, Wong VW, Schumacher BL, Gortz S, Masuda K, Bugbee WD, Sah RL: Shaped, stratified, scaffold-free grafts for articular cartilage defects. Clin Orthop Relat Res 466:1912-20, 2008. PMID:18506565 PMCID:PMC2584257 DOI:10.1007/s11999-008-0291-7

Hwang J, Bae WC, Shieu W, Lewis CW, Bugbee WD, Sah RL: Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis. Arthritis Rheum 58:3831-42, 2008. DOI:10.1002/art.24069

Hwang J, Gortz S, Sah RL, Bugbee WD: Osteochondral graft transfer - techniques, outcomes, and the future. US Musculoskeletal Review 3:75-80, 2008.

Kitahara S, Nakagawa K, Sah RL, Wada Y, Ogawa T, Moriya H, Masuda K : In vivo maturation of scaffold-free engineered articular cartilage on hydroxyapatite. Tissue Eng 14:1905-13, 2008. DOI:10.1089/ten.tea.2006.0419

Klisch SM, Asanbaeva A, Oungoulian SR, Masuda K, Thonar EJ, Davol A, Sah RL: A cartilage growth mixture model with collagen remodeling: validation protocols. J Biomech Eng 130:031006, 2008.

Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D'Lima D, Lotz M: The effect of glycosaminoglycan loss on chrondrocyte viability. Arthritis Rheum 58:1076-85, 2008. DOI:10.1002/art.23381

Schmidt TA, Gastelum NS, Han EH, Nugent-Derfus GE, Schumacher BL, Sah RL: Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1alpa, IGF-I, and TGF-beta1. Osteoarthritis Cartilage 16:90-7, 2008. DOI:10.1016/j.joca.2007.05.009

Temple-Wong MM, Wong VW, Nguyen QT, Keifer KM, Harith HH, Bugbee WD, Lotz M, Sah RL: Modulation of in vitro wear of articulating cartilage: effect of synovial fluid and cartilage degeneration. Osteoarthritis Cartilage 16:S200, 2008.

Williams GM, Klisch SM, Sah RL: Bioengineering cartilage growth, maturation and form. Pediatr Res 63:527-34, 2008.

Wong BL, Bae WC, Chun J, Gratz KR, Lotz M, Sah RL: Biomechanics of cartilage articulation: effects of lubrication and degeneration on shear deformation. Arthritis Rheum 58:2065-74, 2008.

Wong BL, Bae WC, Gratz KR, Sah RL: Shear deformation kinematics during cartilage articulation: effect of lubrication, degeneration, and stress relaxation. Mol Cell Biomech 5:197-206, 2008.

Asanbaeva A, Masuda K, Thonar EJ-MA, Klisch SM, Sah RL: Mechanisms of cartilage growth: Modulation of balance between proteoglycan and collagen in vitro using chondroitinase ABC. Arthritis Rheum 56:188-98, 2007. DOI:10.1002/art.22298

Bae WC, Schumacher BL, Sah RL: Indentation probing of human articular cartilage: effect on chondrocyte viability. Osteoarthritis Cartilage 15:9-18, 2007. DOI:10.1016/j.joca.2006.06.007

Ball ST, Jadin KD, Allen RT, Schwartz AK, Sah RL, Brage ME: Chondrocyte viability after intra-articular calcaneus fractures in humans. Foot Ankle Int 28:665-8, 2007.

Blewis ME, Nugent-Derfus GE, Schmidt TA, Schumacher BL, Sah RL: A model of synovial fluid lubricant composition in normal and injured joints. Eur Cell Mater 13:26-39, 2007.

Blewis ME, Schumacher BL, Klein TJ, Schmidt TA, Voegtline MS, Sah RL: Microenvironment regulation of PRG4 phenotype of chondrocytes. J Orthop Res 25:685-95, 2007.

Chawla K, Klein TJ, Schumacher BL, Jadin KD, Shah BH, Nakagawa K, Wong VW, Chen AC, Masuda K, Sah RL: Short-term retention of labeled chondrocyte subpopulations in stratified tissue-engineered cartilaginous constructs implanted in vivo in mini-pigs. Tissue Eng 13:1525-37, 2007. DOI:10.1089/ten.2007.0044

Ficklin T, Thomas G, Barthel JC, Asanbaeva A, Thonar EJ-MA, Masuda K, Chen AC, Sah RL, Davol A, Klisch SM: Articular cartilage mechanical and biochemical property relations before and after in vivo growth. J Biomech 40:3607-14, 2007. DOI:10.1016/j.jbiomech.2007.06.005

Hicks DL, Sage AB, Shelton E, Schumacher BL, Sah RL, Watson D: Effect of bone morphogenetic proteins 2 and 7 on septal chondrocytes in alginate. Otolaryngol Head Neck Surg 136:373-9, 2007.

Jadin KD, Bae WC, Schumacher BL, Sah RL: Three-dimensional (3-D) imaging of chondrocytes in articular cartilage: Growth-associated changes in cell organization. Biomaterials 28:230-9, 2007. DOI:10.1016/j.biomaterials.2006.08.053

Klein TJ, Chaudhry M, Bae WC, Sah RL: Depth-dependent biomechanical and biochemical properties of fetal, newborn, and tissue-engineered articular cartilage. J Biomech 40:182-90, 2007. DOI:10.1016/j.jbiomech.2005.11.002

Klein TJ, Sah RL: Modulation of depth-dependent properties in tissue-engineered cartilage with a semi-permeable membrane and perfusion: a continuum model of matrix metabolism and transport. Biomech Model Mechanobiol 6:21-32, 2007.

Liu Tsang V, Chen AA, Cho LM, Jadin KD, Sah RL, DeLong S, West JL, Bhatia SN: Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J 21:790-801, 2007.

Nugent-Derfus GE, Chan AH, Schumacher BL, Sah RL: PRG4 exchange between the articular cartilage surface and synovial fluid. J Orthop Res 25:1269-76, 2007.

Nugent-Derfus GE, Takara T, O'Neill JK, Cahill SB, Gortz S, Pong T, Inoue H, Aneloski NM, Wang WW, Vega KI, Klein TJ, Hsieh-Bonassera ND, Bae WC, Burke JD, Bugbee WD, Sah RL: Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthritis Cartilage 15:566-74, 2007. DOI:10.1016/j.joca.2006.10.015

Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL, Sah RL: Boundary lubrication of articular cartilage: Role of synovial fluid constituents. Arthritis Rheum 56:882-91, 2007.

Schmidt TA, Sah RL: Effect of synovial fluid on boundary lubrication of articular cartilage. Osteoarthritis Cartilage 15:35-47, 2007. DOI:10.1016/j.joca.2006.06.005

Temple MM, Bae WC, Chen MQ, Lotz M, Amiel D, Coutts RD, Sah RL: Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 15:1042-52, 2007. DOI:10.1016/j.joca.2007.03.005

Williams GM, Lin JW, Sah RL: Cartilage reshaping via in vitro mechanical loading. Tissue Eng 13:2903-11, 2007. DOI:10.1089/ten.2007.0053

Akeda K, An HS, Okuma M, Attawia M, Miyamoto K, Thonar EJ-MA, Lenz ME, Sah RL, Masuda K: Platelet-rich plasma stimulates porcine articular chondrocyte proliferation and matrix biosynthesis. Osteoarthritis Cartilage 14:1272-80, 2006. DOI:10.1016/j.joca.2006.05.008

Albrecht DR, Underhill GH, Wassermann TB, Sah RL, Bhatia SN: Probing the role of multicellular organization in three-dimensional microenvironments. Nat Methods 3:369-75, 2006.

Alexander TH, Sage AB, Schumacher BL, Sah RL, Watson D: Human serum for tissue engineering of human nasal septal cartilage. Otolaryngol Head Neck Surg 135:397-403, 2006.

Bae WC, Lewis CW, Levenston ME, Sah RL: Indentation testing of human articular cartilage: effects of probe tip geometry and indentation depth on intra-tissue strain. J Biomech 39:1039-47, 2006.

Borazjani BH, Chen AC, Bae WC, Patil S, Sah RL, Firestein GS, Bugbee WD: Effect of impact on chondrocyte viability during insertion of human osteochondral grafts. J Bone Joint Surg 88:1934-43, 2006.

Chawla K, Klein TJ, Schumacher BL, Schmidt TA, Voegtline MS, Thonar EJ-MA, Masuda K, Sah RL: Tracking chondrocytes and assessing their proliferation with PKH26: effects on secretion of proteoglycan 4 (PRG4). J Orthop Res 24:1499-508, 2006.

Gratz KR, Wong VW, Chen AC, Fortier LA, Nixon AJ, Sah RL: Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage. J Biomech 39:138-46, 2006. DOI:10.1016/j.jbiomech.2004.10.016

Hicks DL, Sage AB, Schumacher BL, Jadin KD, Agustin RM, Sah RL, Watson D: Stored human septal chondrocyte viability analyzed by confocal microscopy. Arch Otolaryngol Head Neck Surg 132:1137-42, 2006.

Klein TJ, Schumacher BL, Blewis ME, Schmidt TA, Voegtline MS, Thonar EJ-MA, Masuda K, Sah RL: Tailoring secretion of proteoglycan 4 (PRG4) in tissue-engineered cartilage. Tissue Eng 12:1429-39, 2006. DOI:10.1089/ten.2006.12.1429

Li J, Jadin K, Masuda K, Sah RL, Muehleman C: Characterization of lesions of the talus and description of tram-track lesions. Foot Ankle Int 27:344-55, 2006.

Masuda K, Pfister BE, Sah RL, Thonar EJ-MA: Osteogenic protein-1 promotes the formation of tissue-engineered cartilage using the alginate-recovered-chondrocyte method. Osteoarthritis Cartilage 14:384-91, 2006.

Nugent GE, Aneloski NM, Schmidt TA, Schumacher BL, Voegtline MS, Sah RL: Dynamic shear stimulation of bovine cartilage biosynthesis of proteoglycan 4 (PRG4). Arthritis Rheum 54:1888-96, 2006.

Nugent GE, Schmidt TA, Schumacher BL, Voegtline MS, Bae WC, Jadin KD, Sah RL: Static and dynamic compression regulate cartilage metabolism of PRoteoGlycan 4 (PRG4). Biorheology 43:191-200, 2006.

Richmon JD, Sage AB, Wong VW, Chen AC, Sah RL, Watson D: Compressive biomechanical properties of human nasal septal cartilage. Am J Rhinol 20:496-501, 2006.

Temple MM, Xue Y, Chen MQ, Sah RL: Interleukin-1alpha induction of tensile weakening associated with collagen degradation in bovine articular cartilage. Arthritis Rheum 54:3267-76, 2006.

Akeson WH, Massie JB, Huang B, Giurea A, Sah R, Garfin SR, Kim CW: Topical high-molecular-weight hyaluronan and a roofing barrier sheet equally inhibit postlaminectomy fibrosis. Spine J 5:180-90, 2005.

Albrecht DR, Liu Tsang V, Sah RL, Bhatia SN: Photo- and electropatterning of hydrogel-encapsulated living cell arrays. Lab Chip 5:111-8, 2005.

Allen T, Robertson CM, Pennock AT, Bugbee WD, Harwood FL, Wong VW, Chen AC, Sah RL, Amiel D: Analysis of stored osteochondral allografts at the time of surgical implantation. Am J Sports Med 33:1479-84, 2005.

Chia SH, Homicz MR, Schumacher BL, Thonar EJ, Masuda K, Sah RL, Watson D: Characterization of human nasal septal chondrocytes cultured in alginate. J Am Coll Surg 200:691-704, 2005.

Englert C, McGowan KB, Klein TJ, Giurea A, Schumacher BL, Sah RL: Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum 52:1091-9, 2005.

Hicks DL, Sage AB, Schumacher BL, Sah RL, Watson D: Growth and phenotype of low-density nasal septal chondrocyte monolayers. Otolaryngol Head Neck Surg 133:417-22, 2005. DOI:doi:10.1016/j.otohns.2005.03.084

Jadin KD, Wong BL, Bae WC, Li KW, Williamson AK, Schumacher BL, Price JH, Sah RL: Depth-varying density and organization of chondrocyte in immature and mature bovine articular cartilage assessed by 3D imaging and analysis. J Histochem Cytochem 53:1109-19, 2005. DOI:10.1369/jhc.4A6511.2005

Klisch SM, Sah RL, Hoger A: A cartilage growth mixture model for infinitesimal strains: solutions of boundary-value problems related to in vitro growth experiments. Biomech Model Mechanobiol 3:209-23, 2005.

Lewis CW, Williamson AK, Chen AC, Bae WC, Temple MM, Wong VW, Nugent GE, James SP, Wheeler DL, Sah RL, Kawcak CE: Evaluation of subchondral bone mineral density associated with articular cartilage structure and integrity in normal equine joints with different functional demands. Am J Vet Res 66:1823-9, 2005.

McGowan KB, Sah RL: Treatment of cartilage with beta-aminopropionitrile accelerates subsequent collagen maturation and modulates integrative repair. J Orthop Res 23:594-601, 2005.

Miyamoto K, An HS, Sah RL, Akeda K, Okuma M, Otten L, Thonar EJ-MA, Masuda K: Exposure to pulsed low intensity ultrasound stimulates extracellular matrix metabolism of bovine intervertebral disc cells cultured in alginate beads. Spine 30:2398-405, 2005.

Richmon JD, Sage AB, Shelton E, Schumacher BL, Sah RL, Watson D: Effect of growth factors on cell proliferation, matrix deposition, and morphology of human nasal septal chondrocytes cultured in monolayer. Laryngoscope 115:1553-60, 2005.

Richmon JD, Sage AB, Wong VW, Chen AC, Pan C, Sah RL, Watson D: Tensile biomechanical properties of human nasal septal cartilage. Am J Rhinol 19:617-22, 2005.

Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL: Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res 23:562-8, 2005.

Williams GM, Klein TJ, Sah RL: Cell density alters matrix accumulation in two distinct fractions and the mechanical integrity of alginate-chondrocyte constructs. Acta Biomater 1:625-33, 2005.

Albrecht DR, Sah RL, Bhatia SN: Geometric and material determinants of patterning efficiency by dielectrophoresis. Biophys J 87:2131-47, 2004.

Bae WC, Law AW, Amiel D, Sah RL: Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repair. Ann Biomed Eng 32:360-9, 2004.

Ball ST, Amiel D, Williams SK, Tontz W, Chen AC, Sah RL, Bugbee WD: The effects of storage on fresh human osteochondral allografts. Clin Orthop Relat Res 418:246-52, 2004.

Chia SH, Schumacher BL, Klein TJ, Thonar EJ, Masuda K, Sah RL, Watson D: Tissue-engineered human nasal septal cartilage using the alginate-recovered-chondrocyte method. Laryngoscope 114:38-45, 2004.

Harmel JL, Lewis CW, Sah RL, Kawcak CE, Wheeler DL: An assessment of equine cartilage degeneration. Biomed Sci Instrum 40:261-5, 2004.

Lane JG, Massie JB, Ball ST, Amiel ME, Chen AC, Bae WC, Sah RL, Amiel D: Follow-up of osteochondral plug transfers in a goat model: a 6-month study. Am J Sports Med 32:1440-50, 2004.

Nugent GE, Law AW, Wong EG, Temple MM, Bae WC, Chen AC, Kawcak CE, Sah RL: Site- and exercise-related variation in structure and function of cartilage from equine distal metacarpal condyle. Osteoarthritis Cartilage 12:826-33, 2004.

Sah RL: Interface and bulk regions in the repair, regeneration, and replacement of articular cartilage. J Musculoskelet Neuronal Interact 4:393-5, 2004.

Schmidt TA, Schumacher BL, Klein TJ, Voegtline MS, Sah RL: Synthesis of proteoglycan 4 by chondrocyte subpopulations in cartilage explants, monolayer cultures, and resurfaced cartilage cultures. Arthritis Rheum 50:2849-57, 2004.

Bae WC, Temple MM, Amiel D, Coutts RD, Niederauer GG, Sah RL: Indentation testing of human cartilage: sensitivity to articular surface degeneration. Arthritis Rheum 48:3382-94, 2003.

DiMicco MA, Sah RL: Dependence of cartilage matrix composition on biosynthesis, diffusion, and reaction. Transport Porous Media 50:57-73, 2003.

Giurea A, Klein TJ, Chen AC, Goomer RS, Coutts RD, Akeson WH, Amiel D, Sah RL: Adhesion of perichondrial cells to a polylactic acid scaffold. J Orthop Res 21:584-9, 2003.

Homicz MR, Chia SH, Schumacher BL, Masuda K, Thonar EJ, Sah RL, Watson D: Human septal chondrocyte redifferentiation in alginate, polyglycolic acid scaffold, and monolayer culture. Laryngoscope 113:25-32, 2003.

Homicz MR, McGowan KB, Lottman LM, Beh G, Sah RL, Watson D: A compositional analysis of human nasal septal cartilage. Arch Facial Plast Surg 5:53-8, 2003.

Klein TJ, Schumacher BL, Schmidt TA, Li KW, Voegtline MS, Masuda K, Thonar EJ-MA, Sah RL: Tissue engineering of stratified articular cartilage from chondrocyte subpopulations. Osteoarthritis Cartilage 11:595-602, 2003.

Klisch SM, Chen SS, Sah RL, Hoger A: A growth mixture theory for cartilage with application to growth-related experiments on cartilage explants. J Biomech Eng 125:169-79, 2003.

Kurtis MS, Schmidt TA, Bugbee WD, Loeser RF, Sah RL: Integrin-mediated adhesion of human articular chondrocytes to cartilage. Arthritis Rheum 48:110-8, 2003.

Li KW, Wang AS, Sah RL: Microenvironment regulation of extracellular signal--regulated kinase activity in chondrocytes. Arthritis Rheum 48:689-99, 2003.

Masuda K, Sah RL, Hejna MJ, Thonar EJ-MA: A novel two-step method for the formation of tissue engineered cartilage: the alginate-recovered-chondrocyte (ARC) method. J Orthop Res 21:139-48, 2003.

Williams SK, Amiel D, Ball ST, Allen RT, Wong VW, Chen A, Sah RL, Bugbee WD: Prolonged storage effects on the articular cartilage of fresh human osteochondral allografts. J Bone Joint Surg 85:2111-20, 2003.

Williamson AK, Chen AC, Masuda K, Thonar EJ-MA, Sah RL: Tensile mechanical properties of bovine articular cartilage: variations with growth and relationship to collagen network components. J Orthop Res 21:872-80, 2003. DOI:10.1016/S0736-0266(03)00030-5

Williamson AK, Masuda K, Thonar EJ-MA, Sah RL: Growth of immature articular cartilage in vitro: correlated variation in tensile biomechanical and collagen network properties. Tissue Eng 9:625-34, 2003. DOI:10.1089/107632703768247322

Chen AC, Temple MM, Ng DM, Verzijl N, DeGroot J, TeKoppele JM, Sah RL: Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage. Arthritis Rheum 46:3212-7, 2002.

Davisson T, Kunig S, Chen AC, Sah RL, Ratcliffe A: Static and dynamic compressions modulate matrix metabolism in tissue engineered cartilage. J Orthop Res 20:842-8, 2002.

Davisson TH, Sah RL, Ratcliffe AR: Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures. Tissue Eng 8:807-16, 2002. DOI:10.1089/10763270260424169

DiMicco MA, Waters SN, Akeson WH, Sah RL: Integrative articular cartilage repair: dependence on developmental stage and collagen metabolism. Osteoarthritis Cartilage 10:218-25, 2002.

Giurea A, DiMicco MA, Akeson WH, Sah RL: Development-associated differences in integrative cartilage repair: roles of biosynthesis and matrix. J Orthop Res 20:1274-81, 2002.

Homicz MR, Schumacher BL, Sah RL, Watson D: Effects of serial expansion of septal chondrocytes on tissue-engineered neocartilage composition. Otolaryngol Head Neck Surg 127:398-408, 2002.

Hsieh AH, Sah RL, Sung KLP: Biomechanical regulation of type I collagen gene expression in ACLs in organ culture. J Orthop Res 20:325-31, 2002.

McGowan KB, Kurtis MS, Lottman LM, Watson D, Sah RL: Biochemical quantification of DNA in human articular and septal cartilage using PicoGreen and Hoechst 33258. Osteoarthritis Cartilage 10:580-7, 2002. DOI:10.1053/joca.2002.0794

Sohn DH, Lottman LM, Lum LY, Kim S-G, Pedowitz RA, Coutts RD, Sah RL: Effect of gravity on localization of chondrocytes implanted in cartilage defects. Clin Orthop Relat Res 394:254-62, 2002.

Chen AC, Bae WC, Schinagl RM, Sah RL: Depth- and strain-dependent mechanical and electromechanical properties of full-thickness bovine articular cartilage in confined compression. J Biomech 34:1-12, 2001.

Chen SS, Falcovitz YH, Schneiderman R, Maroudas A, Sah RL: Depth-dependent compressive properties of normal aged human femoral head articular cartilage. Osteoarthritis Cartilage 9:561-9, 2001.

Coutts RD, Healey RM, Ostrander R, Sah RL, Goomer R, Amiel D: Matrices for cartilage repair. Clin Orthop Relat Res 391S:271-9, 2001.

DiMicco MA, Sah RL: Integrative cartilage repair: adhesive strength is correlated with collagen deposition. J Orthop Res 19:1105-12, 2001.

Kurtis MS, Tu BP, Gaya OA, Mollenhauer J, Knudson W, Loeser RF, Knudson CB, Sah RL: Mechanisms of chondrocyte adhesion to cartilage: role of beta 1 integrins, CD44, and annexin V. J Orthop Res 19:1122-30, 2001.

Lane JG, Tontz WL, Bae WC, Chen AC, Sah RL, Amiel D: A morphological, biochemical, and biomechanical assessment of short term effects of osteochondral autograft plug transfer in an animal model. Arthroscopy 17:856-63, 2001.

Li KW, Williamson AK, Wang AS, Sah RL: Growth responses of cartilage to static and dynamic compression. Clin Orthop Relat Res 391S:34-48, 2001.

Riley SL, Dutt S, de la Torre R, Chen AC, Sah RL, Ratcliffe A: Formulation of PEG-based hydrogels affects tissue-engineered cartilage construct characteristics. J Mater Sci Mater Med 12:983-90, 2001.

Williamson AK, Chen AC, Sah RL: Compressive properties and function-composition relationships of developing bovine articular cartilage. J Orthop Res 19:1113-21, 2001.

Dounchis J, Bae WC, Chen AC, Sah RL, Coutts RD, Amiel D: Cartilage repair with autogenic perichondrium cell and polylactic acid grafts. Clin Orthop Relat Res 377:248-64, 2000.

Jin G, Sah RL, Li Y-S, Lotz M, Shyy JY-J, Chien S: Biomechanical regulation of matrix metalloproteinase-9 in chondrocytes. J Orthop Res 18:899-908, 2000.

Kobayashi K, Healey RM, Sah RL, Clark JJ, Tu BP, Goomer RS, Akeson WH, Amiel D: A novel method for the quantitative assessment of cell migration: a study on the motility of anterior cruciate (ACL) and medial collateral ligament (MCL) cells. Tissue Eng 6:29-38, 2000. DOI:10.1089/107632700320865

Lee MC, Sung K-LP, Kurtis MS, Akeson WH, Sah RL: Adhesive force of chondrocytes to cartilage: a micropipette study of the effects of chondroitinase ABC. Clin Orthop Relat Res 370:286-94, 2000.

Li KW, Falcovitz YH, Nagrampa JP, Chen AC, Lottman LM, Shyy YJ, Sah RL: Mechnical compression modulates proliferation of transplanted chondrocytes. J Orthop Res 18:374-82, 2000.

Sonoda M, Harwood FL, Amiel ME, Moriya H, Temple MM, Chang DG, Lottman LM, Sah RL, Amiel D: The effects of hyaluronan on tissue healing following meniscal injury and repair in a rabbit model. Am J Sports Med 28:90-7, 2000.

Ahsan T, Lottman LM, Harwood FL, Amiel D, Sah RL: Integrative cartilage repair by beta-aminoproprionitrile. J Orthop Res 17:850-7, 1999.

Ahsan T, Sah RL: Biomechanics of integrative cartilage repair. Osteoarthritis Cartilage 7:29-40, 1999.

Schinagl RM, Kurtis MS, Ellis KD, Chien S, Sah RL: Effect of seeding duration on the strength of chondrocyte adhesion to articular cartilage. J Orthop Res 17:121-9, 1999.

Amiel D, Chu CR, Sah RL, Coutts RD: Tissue engineering of articular cartilage: perichondrial cells in osteochondral repair. Cells Mat 8:161-74, 1998.

Chen AC, Sah RL: The effect of static compression on proteoglycan synthesis by chondrocytes transplanted to articular cartilage in vitro. J Orthop Res 16:542-50, 1998.

Chang DG, Iverson EP, Schinagl RM, Sonoda M, Amiel D, Coutts RD, Sah RL: Quantitation and localization of cartilage degeneration following the induction of osteoarthritis in the rabbit knee. Osteoarthritis Cartilage 5:357-72, 1997.

Chen AC, Nagrampa JP, Schinagl RM, Lottman LM, Sah RL: Chondrocyte transplantation to articular cartilage explants in vitro. J Orthop Res 15:791-802, 1997. DOI:10.1002/jor.1100150602

Chen AC, Nguyen TT, Sah RL: Streaming potentials during the confined compression creep test of normal and proteoglycan-depleted cartilage. Ann Biomed Eng 25:269-77, 1997.

Chu CR, Dounchis JS, Yoshioka M, Sah RL, Coutts RD, Amiel D: Osteochondral repair using perichondrial cells: a one year study in rabbits. Clin Orthop Relat Res 340:220-9, 1997.

Coutts RD, Sah RL, Amiel D: Effects of growth factors on cartilage repair. Instr Course Lect 46:487-94, 1997.

Sah RL, Yang AS, Chen AC, Hant JJ, Halili RB, Yoshioka M, Amiel D, Coutts RD: Physical properties of rabbit articular cartilage after transection of anterior cruciate ligament. J Orthop Res 15:197-203, 1997. DOI:10.1002/jor.1100150207

Schinagl RM, Gurskis D, Chen AC, Sah RL: Depth-dependent confined compression modulus of full-thickness bovine articular cartilage. J Orthop Res 15:499-506, 1997.

Sah RL, Trippel SB, Grodzinsky AJ: Differential effects of serum, insulin-like growth factor-I, and fibroblast growth factor-2 on the maintenance of cartilage physical properties during long-term culture. J Orthop Res 14:44-52, 1996.

Schinagl RM, Ting MK, Price JH, Sah RL: Video microscopy to quantitate the inhomogeneous equilibrium strain within articular cartilage during confined compression. Ann Biomed Eng 24:500-12, 1996.

Reindel ES, Ayroso AM, Chen AC, Chun DM, Schinagl RM, Sah RL: Integrative repair of articular cartilage in vitro: adhesive strength of the interface region. J Orthop Res 13:751-60, 1995. DOI:10.1002/jor.1100130515

Sah RL, Amiel D, Coutts RD: Tissue engineering of articular cartilage. Curr Opin Orthop 6:52-60, 1995.

Kim YJ, Sah RL, Grodzinsky AJ, Plaas AHK, Sandy JD: Mechanical regulation of cartilage biosynthetic behavior: physical stimuli. Arch Biochem Biophys 311:1-12, 1994.

Sah RL, Chen AC, Grodzinsky AJ, Trippel SB: Differential effects of bFGF and IGF-I on matrix metabolism in calf and adult bovine cartilage explants. Arch Biochem Biophys 308:137-47, 1994. DOI:10.1006/abbi.1994.1020

Sah RL, Doong JYH, Grodzinsky AJ, Plaas AHK, Sandy JD: Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants. Arch Biochem Biophys 286:20-9, 1991.

Sah RL, Grodzinsky AJ, Plaas AHK, Sandy JD: Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants. Biochem J 267:803-8, 1990.

Sah RL, Kim YJ, Doong JH, Grodzinsky AJ, Plaas AHK, Sandy JD: Biosynthetic response of cartilage explants to dynamic compression. J Orthop Res 7:619-36, 1989.

Kim YJ, Sah RLY, Doong JYH, Grodzinsky AJ: Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 174:168-76, 1988. DOI:10.1016/0003-2697(88)90532-5